|
| |
ProMass:
A CLA weight management complex
General Description:
As you read health magazines today you may find advertisements that tell you eating a burger, a few slices of cheese, and a milkshake for dinner can help you get in better shape. This claim may sound contradictory to what you know to be true; however there is some scientific basis. While we know that the high levels of saturated fats or cholesterol found in these foods negate any health benefits they may have, research has indicated that an isolated ingredient common to these food groups may provide us with important health benefits. Conjugated Linoleic Acid (CLA), the novel ingredient found in beef and dairy products, is a natural derivative of the omega-6 polyunsaturated fatty acid, linoleic acid. Polyunsaturated fatty acids (PUFAs) such as linoleic acid have been at the forefront of medical research in recent years due to their ability to encourage healthy cholesterol levels and heart function, maintain supple and healthy skin, and reduce inflammation in joints. CLA is also gaining recognition in the medical field, but for reasons much different than its predecessor linoleic acid. CLA has become widely known for its ability to aid in weight management, and has shown promise in cancer prevention, immune modulation, diabetes, and atherosclerosis. Neways
ProMass has been formulated to aid in a weight management program while providing the body with the unique health-promoting benefits of CLA.
CLA is a collective term used to describe a mixture of structural isomers of linoleic acid. These structural isomers have conjugated double bonds, whereas the linoleic acid molecule has non-conjugated bonds. There are at least eight different CLA isomers; however the two most common and biologically active isomers are the c9 t11 and the t10 c12 forms.[1] The CLA found in Neways
ProMass is a blend of these two highly active forms.
Cattle are able to convert dietary linoleic acid (obtained from grasses) into conjugated linoleic acid in their digestive tracts. Humans, however, are unable to manufacture CLA and must obtain it from beef and dairy products in the diet. Beef and diary products, unfortunately, are also high in saturated fats and cholesterol, which have been implicated as major factors in the development of obesity, heart disease, and various cancers. CLA supplementation affords all of the health benefits of CLA without the additional unhealthy fats and cholesterol of dietary CLA sources.
The effects of CLA on weight management and body composition have been extensively studied. CLA has been shown to liquefy fatty deposits and increase the metabolic rate, enabling the body to better use stored fats as energy.[2],[3] In addition, CLA may reduce fat deposition through inhibition of lipoprotein lipase, an enzyme which enables fat globules in the blood to readily enter fat cells.[4],[1]. Studies have also shown CLA supplementation to cause an increase in skeletal muscle mass, thereby improving overall body composition.[4]
The cancer preventive effects of CLA have also been studied. Although CLA does act as an antioxidant, a 1991 study found a discrepancy between the antioxidant efficacy of CLA and its anticarcinogenic potency, suggesting that other mechanisms in addition to antioxidant action are likely involved in CLA's cancer protection.[5] Since 1991, various methods of cancer prevention by CLA have been shown both in vitro and in vivo. These methods involve CLA's ability to: decrease prostaglandin E2 production,[6] suppress processes of neoplastic promotion/progression,[7] act as an agonist to PPARgamma transcription factor (commonly expressed by human cancer cell lines),[8] and produce a substance that protects from peroxides.[9]
In addition to protecting against cancer, CLA has been shown to have other beneficial immune-modulating properties.[10] In clinical studies, CLA has enhanced the production of interleukin-2, a substance that can improve the body's response to disease by stimulating the growth of certain disease-fighting blood cells.[11] CLA can also enhance T cell proliferation, thereby improving cell-mediated immunity.[11]
CLA supplementation can be of great benefit to persons with diabetes or possibly in the prevention of diabetes. CLA has shown promise in reversing the adipocyte insulin resistance that maintains hyperglycemia in type 2 diabetes,[12] and may normalize impaired glucose tolerance in diabetics or pre-diabetics.[13].
Like its precursor linoleic acid, CLA also has shown benefits in the regulation of plasma lipoproteins and aortic atherosclerosis. Although its mechanism of action is unclear, CLA has been shown to have a significant cholesterol lowering effect. One theory on the mechanism of CLA's cholesterol lowering effect holds that CLA may be involved in down-regulating the activity of intestinal acyl coenzyme A: cholesterol acyltransferase, an enzyme associated with cholesterol absorption.[14] One study reported that rabbits fed an atherogenic diet and supplemented with CLA for 22 weeks had a significantly better LDL/HDL ratio and lower plasma triglyceride and LDL-cholesterol levels than control animals. Furthermore, the rabbits supplemented with CLA had fewer aortic fatty lesions and less risk for the development of atherosclerosis.[15] Another study highlighted CLA's antiatherosclerotic effect in hypercholesterolemic hamsters.[16]
Indications and Usage:
Take 1 capsule three times daily. In order to maximize a weight management program, take
ProMass while participating in a consistent exercise program and eating a diet low in saturated fats and calories.
Contraindications and Warnings:
Gastrointestinal upset is possible as a result of high intakes of CLA.[1]
Some evidence suggests CLA might increase vitamin A (retinol) storage in the liver and breast by as much as five-fold.[17] If you are taking vitamin A supplements, be cautious to monitor daily vitamin A intake so as not to exceed 15,000 RE (retinol equivalents) or 50,000 IU.
Ingredients:
Conjugated Linoleic Acid
REFERENCES:
1. Blankson, H., et al., Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr, 2000. 130(12): p. 2943-8.
2. West, D.B., et al., Conjugated linoleic acid persistently increases total energy expenditure in AKR/J mice without increasing uncoupling protein gene expression. J Nutr, 2000. 130(10): p. 2471-7.
3. Park, Y., et al., Evidence that the trans-10,cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 1999. 34(3): p. 235-41.
4. Park, Y., et al., Effect of conjugated linoleic acid on body composition in mice. Lipids, 1997. 32(8): p. 853-8.
5. Ip, C., et al., Mammary cancer prevention by conjugated dienoic derivative of linoleic acid. Cancer Res, 1991. 51(22): p. 6118-24.
6. Kavanaugh, C.J., K.L. Liu, and M.A. Belury, Effect of dietary conjugated linoleic acid on phorbol ester-induced PGE2 production and hyperplasia in mouse epidermis. Nutr Cancer, 1999. 33(2): p. 132-8.
7. Ip, C., J.A. Scimeca, and H. Thompson, Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutr Cancer, 1995. 24(3): p. 241-7.
8. McCarty, M.F., Activation of PPARgamma may mediate a portion of the anticancer activity of conjugated linoleic acid. Med Hypotheses, 2000. 55(3): p. 187-8.
9. MacDonald, H.B., Conjugated linoleic acid and disease prevention: a review of current knowledge. J Am Coll Nutr, 2000. 19(2 Suppl): p. 111S-118S.
10. Sebedio, J.L., S. Gnaedig, and J.M. Chardigny, Recent advances in conjugated linoleic acid research. Curr Opin Clin Nutr Metab Care, 1999. 2(6): p. 499-506.
11. Hayek, M.G., et al., Dietary conjugated linoleic acid influences the immune response of young and old C57BL/6NCrlBR mice. J Nutr, 1999. 129(1): p. 32-8.
12. McCarty, M.F., Toward a wholly nutritional therapy for type 2 diabetes. Med Hypotheses, 2000. 54(3): p. 483-7.
13. Houseknecht, K.L., et al., Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat. Biochem Biophys Res Commun, 1998. 244(3): p. 678-82.
14. Thomas Yeung, C.H., et al., Dietary conjugated linoleic acid mixture affects the activity of intestinal acyl coenzyme A: cholesterol acyltransferase in hamsters. Br J Nutr, 2000. 84(6): p. 935-41.
15. Lee, K.N., D. Kritchevsky, and M.W. Pariza, Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 1994. 108(1): p. 19-25.
16. Nicolosi, R.J., et al., Dietary conjugated linoleic acid reduces plasma lipoproteins and early aortic atherosclerosis in hypercholesterolemic hamsters. Artery, 1997. 22(5): p. 266-77.
17. Banni, S., et al., An increase in vitamin A status by the feeding of conjugated linoleic acid. Nutr Cancer, 1999. 33(1): p. 53-7.
BACK
| |
|
